GESDA brings together, from around the world, people from four communities with different mindsets – Academic, Diplomatic, Impact and Citizens. Together, based on possible science and technology advances that have been identified, and through a methodology called “Anticipatory Situation Room”, they accelerate the development of impactful solutions to emerging challenges. Such solutions will then be translated into concrete actions deployed on a global scale, and could be for example: a new international organization dedicated to science or science policy, a global regulatory body, an innovative framework agreement on science or an international research initiative. Our replicable methodology may provide a proof of concept for a renewed form of multilateralism.